Jews were first present in Seredné in the mid-eighteenth century and the population steadily grew throughout the following century. By 1880, Jews made up 35% of its population.

The community continued to grow in the twentieth century. After World War I a Jewish elementary school served 100 children. Most Jews in Seredné worked as artisans and tradesmen. There were also three butchers, some farmers and several working in professional positions, such as doctors or lawyers.

In 1939, Hungary occupied Seredné. Hungary was allied with Germany and its antisemitic sentiments were shared. As soon as the town was occupied, members of the Jewish community were forced out of their professions.

In 1940 and 1941, dozens were conscripted to forced labor. Some were sent to labor camps, while many others were sent to the eastern front. Most of them died there. In July 1941, Jewish families without Hungarian citizenship were deported to Kamenets-Podolski, Ukraine and were murdered. Following this, several Jews fled to Russia. Some were able to join the Czechoslovakian army, where they too fought on the eastern front.

In April 1944, Seredné’s remaining Jewish population was force-marched to a ghetto in nearby Uzhhorod. In May, they were deported from there to Auschwitz concentration camp.

A few dozen survivors returned to Seredné after the war, but most chose not to stay. There are currently no Jews living in Seredné.